The study has its focus on the advanced thinking ability of the students such as thinking power, judgement and problem solving which are highly in demand today. The subject of the study were fifty-four freshmen from the department of medicine whom were in their second term. Five modules were developed and selected as the immune system according to the field of curriculum which the students were currently on. This was because the subject students were attending the study separately from the regular curriculum, imposing the least burden but showing the best efficiency of learning. The result of the study shows the students' attendance, problem understanding, preparation and learning as a group were very outstanding. In addition, the modules were a joint development by the professors in Clinical Medicine, understanding a strong liaison between Basic Science Medicine and Clinical Medicine. Based on these results, the development on the problem-based learning should continue and the switchover to a regular curriculum should also be examined in depth.
